INTECINCONICETUBAFacultad de Ingenieria

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Materials Engineering | Applications Biocompatible Materials

Applications of Biocompatible Materials

Department of Chemistry. Faculty of Engineering. UBA
Paseo Colón 850, 5th. Floor. (C1063ACV ) Ciudad Autónoma de Buenos Aires.
Phone: +54 11 4343 0891 extension: 121

Research Field

Polymeric materials in controlled drug release.

RESEARCH:
-Polymeric hydrogels: characterization and drug release studies.
-Films, microspheres and tablets.

Members

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Debandi, María Valeria. Engineer. Ayudante Primera.

mdebandi@fi.uba.ar

Melaj, Mariana A. Engineer. Ayudante Primera.

mmelaj@fi.uba.ar

Podzus, Patricia. M.S. Ayudante Primera.

Andisco, Eugenia.

Work Description

This Group is dedicated to the study of biocompatible hydrophilic polymers, characterizing them with respect to its applicability in controlled delivery of drugs (pharmaceuticals, agrochemicals, food additives, cosmetic active substances, etc.) of potential use in different industries. Natural or synthetic polymers (xanthan, chitosan, starch, polyvinyl alcohol) are employed, with special attention in chitosan, derived from chitin in insects and crustaceans. Chitosan is assayed alone or in mixtures with xanthan or starch, crosslinked with glutaraldehyde or other reagents (for example epichlorohydrin or genipin). For the selected materials different aspects such as morphology, swelling, mechanical behaviour, other physicochemical characteristics and the kinetics of drug delivery are studied, in order to evaluate their suitability for the design of controlled release systems.
Hydrogels are assayed in different geometries: slab, microspheres, films obtained from these gels, and tablets with polymeric solid phase, the latter using a fertilizer as model drug.

The hydrophilic polymers are studied in 4 different physical forms:

Hydrogels in plane geometry
Films
Tablets
Microspheres

Hydrogels in plane geometry: This is the type of material used in previous studies of this group with scleroglucan, with pH-sensitive microgels and with polyvinyl alcohol. Currently we are working with hydrogels obtained from one or more compatible polymers (particularly chitosan and xanthan) with incorporation of different molecules to be released.

Films: We study films obtained by various methods from hydrogels in the presence of plasticizers. The films that have better mechanical properties (eg elasticity) are selected to test them as release matrices, including a drug to be released. Furthermore, these materials are characterized with respect to their use as coatings, for example in the food industry.

Tablets: Tablets are obtained from solid hydrophilic polymers containing agrochemicals (eg fertilizers). Xanthan, chitosan, polyvinyl alcohol, chitosan-xanthan blends, etc., are used as a matrix containing a fertilizer. Also, multilayer-films coatings of hydrophilic polymers without drug are used in coated tablets. The objective is to obtain tablets with a release pattern according to the demands of the crop and progress in understanding the processes that determine the behavior.

Microspheres: chitosan microspheres are prepared alone, with magnetic particles or with other nanoparticles. Two of the possible applications are studied: water-soluble drug release and adsorption of contaminants (heavy metals and dyes). Today we continue with the study of adsorption behavior of these microspheres, both in its kinetic and equilibrium aspects.

In summary, the objectives of the work are to study the in vitro release of active compounds included in polymer matrices, get a better structural characterization of the material, as well as advance in the knowledge of the underlying mechanisms of drug release and swelling.